Testicular tumours linked to offsprings' disease

 作者:邱嫘钨     |      日期:2019-03-08 06:02:13
GENETIC disease is more likely in the children of older fathers, but why? Part of the answer may be that benign testicular tumours, more common in older men, give rise to sperm containing disease-causing mutations. Anne Goriely of the University of Oxford and her colleagues took tumour cells from men with benign testicular tumours and looked for specific mutations in the FGFR3 and HRAS genes. These mutations have been linked to rare developmental diseases such as achondroplasia, or “dwarfism”, and Costello syndrome,